Conditions adjustment of polycaprolactone nanofibers scaffolds encapsulated with core shells of Au@Se via laser ablation for wound healing applications
| Autor: | M.F.H. Abd El-Kader, M.K. Ahmed, Mohammed S. Al-Mogbel, Mohamed El-Abbasy, A.A. Menazea, A.W. Sadek |
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| Rok vydání: | 2021 |
| Předmět: |
Staphylococcus aureus
Polyesters Composite number Nanofibers chemistry.chemical_element Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Escherichia coli Fourier transform infrared spectroscopy Instrumentation Spectroscopy Wound Healing Laser ablation Dopant 021001 nanoscience & nanotechnology Atomic and Molecular Physics and Optics 0104 chemical sciences chemistry Chemical engineering Nanofiber Polycaprolactone Laser Therapy 0210 nano-technology Selenium |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 259 |
| ISSN: | 1873-3557 |
| Popis: | Au@Se core–shell nanoparticles were obtained via laser ablation technique to be incorporated into polycaprolactone (PCL) nanofibrous scaffolds for wound healing applications at different contributions of Se nanoparticles (SeNPs). The synthesized layers were inspected via X-ray diffraction (XRD) and Fourier transformed infrared (FTIR). Additionally, microstructural and surface morphology were followed with different SeNPs contributions before and after fibroblast culturing. Moreover, Selenium dopant is affected Maximum roughness valley depth while it starts from 0.31 µm at Au@0.0Se@PCL reaching 0.457 µm at Au@12Se@PCL; however, after culturing starts from 0.3833 µm reaching 0.41 µm. Besides, the antibacterial activity was screened, showing the absence of inhibition zones in free selenium composition; however, it grows up reaching 8.3 ± 0.8, and 8.0 ± 0.8 for E. coli and S. aureus, respectively at the maximum contribution of selenium. SeNPs contributed composites show higher cell viability than Selenium free composite that it reaches its max in Au@8.0Se@PCL, recording 95.3 ± 2.3%. Composites show an excellent Wound dressing capability that its performance is directly proportional to selenium content. This significant enrichment of antibacterial activity and cell viability could recommend these composites for additional research in medical applications. |
| Databáze: | OpenAIRE |
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