Oxidative stress and phenotype frequencies of paraoxonase-1 in teratozoospermia
| Autor: | Sahabettin Selek, Hifa Gulru Caglar, Habib Akbulut, Eray Metin Guler, Fatih Gevher, Ömer Faruk Özer, Fatmanur Koktasoglu |
|---|---|
| Přispěvatelé: | KÖKTAŞOĞLU, FATMANUR |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Infertility
Adult Male Urology Teratozoospermia medicine.disease_cause Arylesterase Andrology Endocrinology medicine Humans Polymorphism Genetic biology Aryldialkylphosphatase Paraoxonase General Medicine medicine.disease Oxidants PON1 Phenotype Spermatozoa Healthy Volunteers Ozer O. AKBULUT H. GULER E. M. CAGLAR H. G. GEVHER F. KOKTASOGLU F. SELEK S. -Oxidative stress and phenotype frequencies of paraoxonase-1 in teratozoospermia.- Andrologia 2019 Semen Analysis Oxidative Stress Catalase Case-Control Studies biology.protein Oxidative stress |
| Popis: | Oxidative stress causes infertility in men by affecting especially sperm morphology. The aim of the study was to examine the frequencies of paraoxonase-1 (PON1) phenotypes and the serum PON1, arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, catalase and thiol levels in teratozoospermic infertile men and normospermic fertile men. The study included 184 teratozoospermic infertile men and 72 normospermic fertile men. The double substrate method was employed to determine the phenotype distribution of PON1. The evaluation of sperm morphology was made in accordance with the Kruger's criteria. TAS, catalase and thiol levels were determined to be significantly lower in teratozoospermic infertile men compared to normospermic fertile men. A significant change was not observed in the levels of TOS, PON1 and arylesterase. There was a positive correlation between catalase and thiol levels and sperm morphology. While there were significantly more teratozoospermic men with AA phenotypes compared to normospermic men, there were significantly more persons with AB and BB phenotypes in normospermic men than in teratozoospermic men. As far as we know, such a study was conducted for the first time and suggests that PON1 phenotypic distribution may play a significant role in sterile males because of impaired sperm morphology. |
| Databáze: | OpenAIRE |
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