| Popis: |
Hypoparathyroidism (HPT) is a rare disorder characterized by hypocalcemia and absent or deficient PTH. Few data are available on the natural history and correct management of this disease. Aim: Describe clinical characteristics, treatment, and complications in a group of patients with hypoparathyroidism from 6 referral centers for endocrinological diseases. Secondary, describe how many patients reached guidelines recommendations for rhPTH (1-84) treatment (Brandi ML. JCEM. 2016). M & M: In this retrospective study patients with a diagnosis of HPT of ≥6 months were eligible for inclusion. Patients with pseudohypoparathyroidism were excluded. Demographics, etiology, management, hospitalizations, clinical manifestations and biochemical and DXA values were collected.Results:322 HPT patients were included; mean age was 55.2 ± 16.8 years, 85,7% were women. Mean ageat diagnosis was 43.8 ± 16.8 years and mean follow up time was 4.9 ± 5.1 years. Regarding etiology 90%were post-surgical (50.3% for thyroid cancer, 41% for multinodular goiter, 2.7% primary hyperparathyroidism;3.4% secondary hyperparathyroidism and 2.3% cervical cancer). Non-surgical etiology included: 5 DiGeorge Syndrome, 9 autoimmune and 16 idiopathic. Non-surgical patients were significantly younger (45 ± 19.5 vs.56.3 ± 16.1 years; p |
