Dose-dense and dose-intense chemotherapy for small cell ovarian cancer: 2 cases and review of literature
| Autor: | N. S. Reed, P.D. Correa, R.K. Shrimali |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Paclitaxel medicine.medical_treatment Carboplatin chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Carcinoma Small Cell Ovarian Neoplasms Chemotherapy Taxane business.industry Induction chemotherapy Hematology General Medicine Middle Aged medicine.disease Radiation therapy chemistry Female Prophylactic cranial irradiation Ovarian cancer business |
| Zdroj: | Medical Oncology. 28:766-770 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-010-9509-0 |
| Popis: | Small cell carcinomas of the ovary (SCCO) are rare and aggressive malignant neoplasms carrying a poor prognosis. Although multi-modality treatment including chemotherapy leads to a high initial response rate, the majority of these patients relapse quickly and die within 2 years of diagnosis. Because these tumours are rare, there is no consensus to support any particular approach to management. We present 2 cases and review the relevant literature to make a number of recommendations. The treatment of these unusual cases should to be individually discussed in a multi-disciplinary team and multi-modality treatment including surgery, chemotherapy and radiotherapy should be considered for patients with limited disease. Conservative, fertility-preserving surgery may be considered in younger women with early-stage disease. Induction chemotherapy with weekly dose-dense and dose-intense carboplatin and taxane is useful. Prophylactic cranial irradiation (PCI) may be considered in patients in remission after primary treatment with chemotherapy or surgery. |
| Databáze: | OpenAIRE |
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