Hybrid imaging of complicating osteomyelitis in the peripheral skeleton
| Autor: | Bliede Van den Broeck, Filip Gemmel, Wouter Huysse, Silvie Vanelstraete, Benoit Van Innis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Modality (human–computer interaction) medicine.diagnostic_test business.industry Osteomyelitis General Medicine medicine.disease Imaging modalities Bone Infection Positron emission tomography Peripheral skeleton Positron Emission Tomography Computed Tomography Medical imaging medicine Humans Radiology Nuclear Medicine and imaging Radiology Tomography business |
| Zdroj: | Nuclear medicine communications. 42(9) |
| ISSN: | 1473-5628 |
| Popis: | Diagnosing complicating osteomyelitis (COM) is clinically challenging. Laboratory tests are of limited utility, and other than isolation of the offending organism, diagnostic imaging tests are of paramount importance. Nuclear Medicine techniques play an important role in noninvasive evaluation of osteomyelitis, using both single-photon emission tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals. It is well-known that those conventional imaging modalities are not performing well in the distinction between soft-tissue and deep bone infection due to the lack of anatomical information. These difficulties have been overcome, to a great extent, with the introduction of in-line SPECT-CT and PET-CT systems which have revolutionized the field of diagnostic medical imaging. Hybrid imaging is especially useful in sites of suspected COM with underlying structural bone alterations. The first clinical studies with these integrated hybrid machines in the field of COM, including metallic implants imaging, are highly promising. In summary, WBC/AGA SPECT-CT and FDG-PET-CT seem to be the most accurate hybrid imaging modality for COM of the peripheral bone. However, there are still false positives, especially in aseptic tibial nonunions and/or metallic implants, as well as in the immediate postoperative setting. Furthermore, there is a lack of well-designed large multicentre prospective studies. Hopefully, in the future, the complementary use of morphological and functional hybrid imaging modalities may overcome some of the challenges faced in the assessment of COM. |
| Databáze: | OpenAIRE |
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