Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity
| Autor: | Junyeop Daniel Roh, Myoung Hwan Kim, Hyewon Shin, Christoph Van Riesen, Yeunkum Lee, Daniel J. Whitcomb, Seok-Kyu Kwon, Jeong-Seop Rhee, Julia M. Warburton, Seil Jang, Daeyoung Oh, Doyoun Kim, Jihoon Jo, Heejung Jun, Sun-Gyun Kim, Eunjoon Kim, Won Mah, Hyun Kim, Bong-Kiun Kaang, Jooyeon Woo, Dongmin Lee, Kwangwook Cho, Daniel Choquet, Eric Hosy, Seung Min Um |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Patch-Clamp Techniques Cell Adhesion Molecules Neuronal Guinea Pigs Neural facilitation Immunoglobulins Nonsynaptic plasticity Biology Hippocampus Synaptic Transmission Article Rats Sprague-Dawley Mice 03 medical and health sciences Synaptic augmentation Metaplasticity Animals Humans Receptors AMPA Cells Cultured Neurons Neuronal Plasticity Synaptic scaling musculoskeletal neural and ocular physiology General Neuroscience Intracellular Signaling Peptides and Proteins Membrane Proteins Long-term potentiation Rats Cell biology 030104 developmental biology Synaptic fatigue Gene Expression Regulation nervous system Gene Knockdown Techniques Synaptic plasticity Rabbits Cell Adhesion Molecules Disks Large Homolog 4 Protein Neuroscience |
| Zdroj: | Nature Neuroscience. 19:84-93 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.4176 |
| Popis: | Synaptic adhesion molecules regulate synapse development and plasticity through mechanisms including trans-synaptic adhesion and recruitment of diverse synaptic proteins. We report here that the immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule preferentially expressed in the brain, is a novel and dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPAR glutamate receptors (AMPARs). IgSF11 requires PSD-95 binding for its excitatory synaptic localization. In addition, IgSF11 stabilizes synaptic AMPARs, as shown by IgSF11 knockdown-induced suppression of AMPAR-mediated synaptic transmission and increased surface mobility of AMPARs, measured by high-throughput, single-molecule tracking. IgSF11 deletion in mice leads to suppression of AMPAR-mediated synaptic transmission in the dentate gyrus and long-term potentiation in the CA1 region of the hippocampus. IgSF11 does not regulate the functional characteristics of AMPARs, including desensitization, deactivation, or recovery. These results suggest that IgSF11 regulates excitatory synaptic transmission and plasticity through its tripartite interactions with PSD-95 and AMPARs. |
| Databáze: | OpenAIRE |
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