Thoracolumbar meningeal fibrosis in pugs
| Autor: | Kerstin Lindblad-Toh, Marco Rosati, Cecilia Rohdin, Peter Wohlsein, Karin Hultin Jäderlund, Alexandra Leijon, Jens Häggström, Kaspar Matiasek, Ingrid Ljungvall |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Neurological examination Standard Article 030204 cardiovascular system & hematology Klinisk vetenskap Thoracic Vertebrae 0403 veterinary science Lesion 03 medical and health sciences Myelopathy Dogs 0302 clinical medicine meninges medicine Animals Dog Diseases Prospective Studies Paresis Neurologic Examination lcsh:Veterinary medicine General Veterinary medicine.diagnostic_test business.industry ataxia Meninges spinal cord Magnetic resonance imaging 04 agricultural and veterinary sciences Clinical Science Spinal cord medicine.disease Fibrosis Magnetic Resonance Imaging Standard Articles Pedigree medicine.anatomical_structure Neurology lcsh:SF600-1100 Female SMALL ANIMAL Radiology medicine.symptom Tomography X-Ray Computed business Spinal Cord Compression Vertebral column |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 34, Iss 2, Pp 797-807 (2020) |
| Popis: | Background Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs. Objectives To further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy. Animals Thirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study. Methods Prospective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death. Results Twenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs. Conclusions and clinical importance Meningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|