Cryptolepis sanguinolenta activity against diarrhoeal bacteria
| Autor: | Silvia Viegas, Alexandra Paulo, Ilda Pires, Elsa T. Gomes, Madalena Pimentel, Aida Duarte, José Cabrita |
|---|---|
| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Rok vydání: | 1994 |
| Předmět: |
Diarrhea
Cryptolepis sanguinolenta Microbial Sensitivity Tests medicine.disease_cause Campylobacter jejuni Microbiology chemistry.chemical_compound Drug Discovery medicine Humans Campylobacte Vibrio cholerae Medicine African Traditional Diarrhoeal bacteria Antibacterial agent Pharmacology Plants Medicinal Bacteria biology Plant Extracts Sulfamethoxazole Campylobacter Cryptolepine Bacterial Infections biology.organism_classification Africa Western chemistry Campylobacter coli medicine.drug |
| Zdroj: | Scopus-Elsevier Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/0378-8741(94)90071-x |
| Popis: | Cryptolepine is the main alkaloid of Cryptolepis sanguinolenta (Lindl.) Schlechter, a plant used in traditional medicine in West Africa. The minimal inhibitory concentrations (MICs) of cryptolepine, ethanol and aqueous extracts of Cryptolepis sanguinolenta root were determined for 65 strains of Campylobacter jejuni, 41 strains of Campylobacter coli isolated from sporadic cases of gastroenteritis in Portugal and 86 strains of Vibrio cholerae isolated from patients with enteric infections in Angola, Brazil and Portugal. The ethanol extract activity against Campylobacter strains (MIC90% = 25 microg/ml) is higher than that of co-trimoxazole and sutfamethoxazole and Campvlobacter strains susceptibility for cryptoleprne (MIC90% = 12.5 microg/ml) is equal for ampicillin. The ethanot extract and cryptolepine show some activity against the Vibrio cholerae strains, although their activities are tower than that of tetracycline. lhe results suggest that these roots could be a therapeutic alternative for bacterial etiologic diarrhoea in West Africa. The authors express their thanks to JNICT Portugal for the financial support through the PMCT/C/SAU/749/90 project. |
| Databáze: | OpenAIRE |
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