Spontaneous activity and responses of reticular neurones in monoamine-depleted rats
| Autor: | Enrico Tempesta, Ian Briggs |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Biogenic Amines Serotonin medicine.medical_specialty Reserpine Motor Activity Serotonergic Norepinephrine Internal medicine medicine Animals Premovement neuronal activity Neurons Pharmacology P chlorophenylalanine Chemistry Reticular Formation Fenclonine Acetylcholine Rats Monoamine neurotransmitter Endocrinology Reticular connective tissue Excitatory postsynaptic potential medicine.drug |
| Zdroj: | European Journal of Pharmacology. 57:165-169 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(79)90361-3 |
| Popis: | Depletion of rat brain serotonin by p-chlorophenylalanine (PCPA) pretreatment, or of monoamines by reserpine pretreatment, was associated with reduced spontaneous firing rates of bulbar reticular neurones. Administration of 5-hydroxytryptophan to PCPA-treated rats reversed the reduction of neuronal activity. It is suggested that the results indicate a tonic excitatory serotoninergic input to a significant proportion of these neurones, which is abolished by serotonin depletion. Responses to serotonin and noradrenaline were greater in PCPA-treated and reserpine-treated rats respectively, indicating the development of supersensitivity. |
| Databáze: | OpenAIRE |
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