The Role of miR-23b in Cancer and Autoimmune Disease

Autor: Xing Li, Wen-Cheng Wu, Rui-Heng Chen, Na Wang, Cuiqin Li, Yuan Zhang, Yu-Xin Guo
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
ISSN: 1687-8469
1687-8450
Popis: Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of gene expression. miRNAs are involved in a variety of cellular physiological processes, including cell proliferation, differentiation, and apoptosis. miR-23b have been identified to act both as oncogenes and as tumor suppressors. In addition, miR-23b is related to inflammation resistance to various autoimmune diseases and restrained inflammatory cell migration. The characterization of the specific alterations in the patterns of miR-23b expression in cancer and autoimmune disease has great potential for identifying biomarkers for early disease diagnosis, as well as for potential therapeutic intervention in various diseases. In this review, we summarize the ever-expanding role of miR-23b and its target genes in different models and offer insight into how this multifunctional miRNA modulates tumor cell proliferation and apoptosis or inflammatory cell activation, differentiation, and migration.
Databáze: OpenAIRE
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