Blood biomarkers of common toad Rhinella arenarum following chlorpyrifos dermal exposure
Autor: | Andres Maximiliano Attademo, Candela Soledad Martinuzzi, Paola M. Peltzer, Carlina Colussi, Rafael Carlos Lajmanovich |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
BLOOD
B-esterases Health Toxicology and Mutagenesis Toad B-ESTERASES 010501 environmental sciences Pharmacology Toxicology medicine.disease_cause 01 natural sciences purl.org/becyt/ford/1 [https] 03 medical and health sciences chemistry.chemical_compound Carboxylesterase blood RA1190-1270 biology.animal medicine purl.org/becyt/ford/1.6 [https] Butyrylcholinesterase 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences biology catalase CHLORPYRIFOS DERMAL EXPOSURE biology.organism_classification Rhinella arenarum chemistry Catalase Chlorpyrifos Toxicology. Poisons Toxicity biology.protein CATALASE chlorpyrifos dermal exposure Original Article RHINELLA ARENARUM Oxidative stress |
Zdroj: | Interdisciplinary Toxicology Interdisciplinary Toxicology, Vol 11, Iss 2, Pp 148-154 (2018) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
ISSN: | 1337-9569 1337-6853 |
Popis: | Chlorpyrifos (CPF) is a broad spectrum pesticide commonly used for insect control, has great affinity for lipids and is thus a potential for bioaccumulation in aquatic organisms. The aim of this study was to evaluate the toxicity of CPF using the common toad Rhinella arenarum via dermal uptake in plastic bucket to simulate their natural exposition in ponds. R. arenarum toads were exposed individually to solutions containing a nominal concentration of a commercial formulation of CPF insecticide (5 and 10 mg/L). Different enzyme biomarkers (BChE: butyrylcholinesterase, CbE: carboxylesterase, and CAT: catalase) were measured in blood tissue after exposition. The capacity of pyridine-2-aldoxime methochloride (2-PAM) to reverse OP-inhibited plasma BChE and the ratio of heterophils and lymphocytes (H/L) as hematological indicators of stress were also determined. The normal values of plasma B-sterases (BChE and CbE) were highly inhibited (until ≈ 70%) in toads 48 h after exposure to CPF. The results indicate that 2-PAM produced BChE reactivation as well. The activity of CAT was also inducted for dermal exposure at more than double of that in the control toads (CPF; 5 mg/L). H/L ratios did not reveal a significantly increased stress. The study suggests that CPF via dermal uptake induced neurotoxicity and oxidative stress in the common toad R. areanum. Thus, some blood biomarkers employed in our study (i.e. BChE, CbE, 2-PAM, and CAT) might be used as predictors in health and ecological risk assessment of amphibian populations exposed to CPF. Fil: Lajmanovich, Rafael Carlos. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Peltzer, Paola Mariela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina Fil: Attademo, Andres Maximiliano. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina Fil: Martinuzzi, Candela Soledad. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Saneamiento Ambiental. Cátedra de Ecotoxicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina |
Databáze: | OpenAIRE |
Externí odkaz: |