FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests
| Autor: | Peter Oertel, Svend Kamysek, Jochen K. Schubert, Khushman Taunk, Phillip Trefz, Pritam Sukul, Wolfram Miekisch |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Respiratory rate 01 natural sciences Mass Spectrometry Article Pulmonary function testing Acetone 03 medical and health sciences Young Adult 0302 clinical medicine Hemiterpenes Internal medicine Forced Expiratory Volume Pentanes Respiration medicine Butadienes Humans Respiratory system Tidal volume Volatile Organic Compounds Multidisciplinary Chemistry 010401 analytical chemistry Hemodynamics Exhalation Carbon Dioxide Middle Aged 0104 chemical sciences 3. Good health Surgery Respiratory Function Tests 030228 respiratory system 13. Climate action Cardiology Breathing Female Respiratory minute volume |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Breath volatile organic compound (VOC) analysis can open a non-invasive window onto pathological and metabolic processes in the body. Decades of clinical breath-gas analysis have revealed that changes in exhaled VOC concentrations are important rather than disease specific biomarkers. As physiological parameters, such as respiratory rate or cardiac output, have profound effects on exhaled VOCs, here we investigated VOC exhalation under respiratory manoeuvres. Breath VOCs were monitored by means of real-time mass-spectrometry during conventional FEV manoeuvres in 50 healthy humans. Simultaneously, we measured respiratory and hemodynamic parameters noninvasively. Tidal volume and minute ventilation increased by 292 and 171% during the manoeuvre. FEV manoeuvre induced substance specific changes in VOC concentrations. pET-CO2 and alveolar isoprene increased by 6 and 21% during maximum exhalation. Then they decreased by 18 and 37% at forced expiration mirroring cardiac output. Acetone concentrations rose by 4.5% despite increasing minute ventilation. Blood-borne furan and dimethyl-sulphide mimicked isoprene profile. Exogenous acetonitrile, sulphides, and most aliphatic and aromatic VOCs changed minimally. Reliable breath tests must avoid forced breathing. As isoprene exhalations mirrored FEV performances, endogenous VOCs might assure quality of lung function tests. Analysis of exhaled VOC concentrations can provide additional information on physiology of respiration and gas exchange. |
| Databáze: | OpenAIRE |
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