Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon
| Autor: | Maryvonne Kombila, Christophe Rogier, Jean-Romain Mourou, Frédéric Pagès, Bruno Pradines, Fanny Jarjaval, Thierry Coffinet, Rémi Amalvict |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Insecticides
medicine.medical_specialty Veterinary medicine lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Anopheles gambiae Plasmodium falciparum Biology Risk Assessment lcsh:Infectious and parasitic diseases Insecticide Resistance chemistry.chemical_compound Malaria transmission Anopheles Military Facilities Pyrethrins parasitic diseases medicine Animals Humans lcsh:RC109-216 Gabon Pyrethroid Research biology.organism_classification medicine.disease Virology Malaria Circumsporozoite protein Infectious Diseases chemistry Parasitology Mutation Tropical medicine Insect Proteins Female |
| Zdroj: | Malaria Journal, Vol 9, Iss 1, p 321 (2010) Malaria Journal |
| ISSN: | 1475-2875 |
| Popis: | Background Urban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops. Methods Mosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The Plasmodium falciparum circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down (kdr) resistance and of insensitive acetylcholinesterase resistance were conducted. Results In Libreville, Anopheles gambiae s.s. S form was the only specie of the An. gambiae complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, Anopheles melas (75.5% of catches) and An. gambiae s.s. S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for An. gambiae s.s and 0.28% for An. melas and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both kdr-w and kdr-e mutations in An. gambiae S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville. Conclusion Malaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets. |
| Databáze: | OpenAIRE |
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