Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women
| Autor: | George S. Jackson, Elizabeth Offord-Cavin, Connie M. Weaver, Berdine R. Martin, Munro Peacock, George P. McCabe, Marie Noelle Horcajada, Linda D McCabe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteoporosis chemistry.chemical_element 030209 endocrinology & metabolism Context (language use) Calcium Biochemistry Bone and Bones Placebos 03 medical and health sciences Hesperidin chemistry.chemical_compound 0302 clinical medicine Endocrinology Double-Blind Method Internal medicine medicine Humans Osteoporosis Postmenopausal Aged Calcium metabolism Cross-Over Studies 030109 nutrition & dietetics Postmenopausal women business.industry Calcium Radioisotopes Biochemistry (medical) Middle Aged medicine.disease Crossover study Calcium Dietary Postmenopause chemistry Dietary Supplements Ovariectomized rat Female business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 101:923-927 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. Objective: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. Design: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, 41Ca, from bone. Results: Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04). Conclusion: Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women. |
| Databáze: | OpenAIRE |
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