Initiation and inhibition of subcutaneous calcification
| Autor: | J. W. Boke, A. F. Hegyeli, Fred Leonard, R. J. Ruderman |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Calcium Phosphates
Male Subcutaneous calcification Injections Subcutaneous Endocrinology Diabetes and Metabolism Sodium ATPase chemistry.chemical_element Calcium Phosphates Calcium Chloride chemistry.chemical_compound Adenosine Triphosphate Endocrinology medicine Animals Magnesium Microscopy Interference Microscopy Phase-Contrast Orthopedics and Sports Medicine Amorphous calcium phosphate Adenosine Triphosphatases biology Chemistry Spectrophotometry Atomic Calcinosis General Medicine medicine.disease Phosphate Stimulation Chemical Rats medicine.anatomical_structure Biochemistry Connective Tissue biology.protein Biophysics Blood Vessels Microscopy Polarization Crystallization Subcutaneous tissue Calcification |
| Zdroj: | Calcified Tissue Research. 10:269-279 |
| ISSN: | 1432-0827 0008-0594 |
| DOI: | 10.1007/bf02012558 |
| Popis: | Injection of CaATP solutions subcutaneously in rats resulted in the formation of white, circumscribed, gritty plaques containing amorphous calcium phosphate (Ca/P 1.3–1.5). Dense, rod-shaped deposits were oriented along the fibrous elements and surrounding blood vessels in the subcutaneous connective tissue. The response was dose related, the amount of plaque calcium being about 100 times the amount injected. These results suggest that the calcium phosphate formed from CaATP in the ATPase active subcutaneous tissue may nucleate crystallization. Injection of a solution of CaCl2 having the same concentration as the calcium in the CaATP solution, or of a sodium phosphate solution having the same concentration of phosphorus as the CaATP, did not produce plaques. However, injection of a solution containing both Ca2+ and PO 4 3− produced plaques, although smaller than those formed by injection of CaATP. |
| Databáze: | OpenAIRE |
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