Zika Vaccine Development: Current Status
| Autor: | Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
DENV dengue virus E envelope Dengue virus medicine.disease_cause ZIKV Zika virus Article WHO World Health Organization Zika virus Disease Outbreaks Drug Development medicine C capsid Humans IFN interferon Intensive care medicine Licensure biology business.industry Zika Virus Infection Viral Vaccine ADE antibody-dependent enhancement Viral Vaccines General Medicine biology.organism_classification GBS Guillain-Barré syndrome mRNA messenger RNA IRF IFN response factor Drug development prM premembrane/membrane business |
| Zdroj: | Mayo Clinic Proceedings |
| ISSN: | 1942-5546 0025-6196 |
| Popis: | Zika virus outbreaks have been explosive and unpredictable and have led to significant adverse health effects—as well as considerable public anxiety. Significant scientific work has resulted in multiple candidate vaccines that are now undergoing further clinical development, with several vaccines now in phase 2 clinical trials. In this review, we survey current vaccine efforts, preclinical and clinical results, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection. Whether such vaccines can be developed through to licensure and public availability absent significant financial investment by countries, and other barriers discussed within this article, remains uncertain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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