| Autor: |
Miao Tang, Xiaohong Li, Zhijian J. Chen, Gerald M. McInerney, Maggy Fina, Ming Zeng, Tiana Purrington, Xiaoming Zhan, Zeping Hu, Gabriel K. Pedersen, Eva Marie Y. Moresco, Jianhui Wang, Jin H uk Choi, Xiao Dong Li, Kuan Wen Wang, Bruce Beutler, Ralph J. DeBerardinis, Xiaolei Shi, Gunilla B. Karlsson Hedestam |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Popis: |
Multivalent molecules with repetitive structures including bacterial capsular polysaccharides and viral capsids elicit antibody responses through B cell receptor (BCR) crosslinking in the absence of T cell help. We report that immunization with these T cell–independent type 2 (TI-2) antigens causes up-regulation of endogenous retrovirus (ERV) RNAs in antigen-specific mouse B cells. These RNAs are detected via a mitochondrial antiviral signaling protein (MAVS)–dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production. Deficiency of both MAVS and cGAS, or treatment of MAVS-deficient mice with reverse transcriptase inhibitors, dramatically inhibits TI-2 antibody responses. These findings suggest that ERV and two innate sensing pathways that detect them are integral components of the TI-2 B cell signaling apparatus. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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