Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures
Autor: | Xin-Ying Ji, Muhammad Farhan Khan, Asim Ur Rehman, Mahnoor Baloch, Lei Qian, Dongdong Wu, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Maria Mir |
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Rok vydání: | 2022 |
Předmět: |
0301 basic medicine
Medicine (General) Skin Neoplasms Science (General) Polymers Mn Manganese MSC Melanoma skin cancer PLA-HPG Poly (d-l-lactic acid)-hyperbranched polyglycerol Pharmaceutical Science PATCH1 Patch SCC Squamous cell Carcinoma PCL Poly (ε-caprolactone) Disease 5-ALA 5-aminolevulinic acid PLL Poly (L-lysine) Polyethylene Glycols Q1-390 Drug Delivery Systems hTERT Human telomerase reverse transcriptase 0302 clinical medicine Polymeric nanocarriers Squamous cell carcinoma UV Ultra Violet Gene delivery PDT Photodynamic therapy PLGA Poly (lactide-co-glycolide) copolymers media_common Multidisciplinary Melanoma GNR-PEG-MN PEGylated gold nanorod microneedle CREB response element-binding protein SC Skin cancer PEG Polyethylene glycol IPM Isopropyl myristate 030220 oncology & carcinogenesis HPMC Hydroxypropyl methylcellulose Drug delivery NMSC Non melanoma skin cancer BCC Basal cell carcinoma MNPs Magnetic nanoparticle dPG Dendritic polyglycerol cAMP Cyclic adenosine monophosphate Microneedles Drug medicine.medical_specialty BCCs Basal cell carcinomas SPIO Superparamagnetic iron oxide media_common.quotation_subject NPs Nano Particles MRI Magnetic Resonance Imaging DDS Drug delivery system MNs Microneedles 03 medical and health sciences R5-920 medicine Humans SMO Smoothen Intensive care medicine Biology AIDS Acquired immune deficiency syndrome ComputingMethodologies_COMPUTERGRAPHICS PLA Poly lactic acid PAMAM Poly-amidoamines Cancer HH Hedgehog DIM-D Di indolyl methane derivative medicine.disease Nanostructures Gd Gadolinium 030104 developmental biology MCIR Melanocortin-1 receptor Basal cell carcinoma PAN Polyacrylonitrile 5-FU 5-fluorouracil Skin cancer OTR Organ transplant recipients QDs Quantum dots |
Zdroj: | Journal of Advanced Research, Vol 36, Iss, Pp 223-247 (2022) Journal of Advanced Research |
ISSN: | 2090-1232 |
Popis: | Graphical abstract Highlights • Skin cancer is a fatal public health concern rising continuously all over the world. • Several environmental and genetic risk factors are associated with cutaneous carcinogenesis. • Use of nanocarriers for targeted delivery of anticancer agents is the most advanced approach. • Polymeric structures are suitable for tumor selective delivery of drugs, genes and imaging agents. • Polymeric micro/nanostructures have successfully used for combination anticancer therapies. Background Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers, and lack of efficient drug delivery systems, it is essential to surge the possible ways to prevent or cure the disease. Aim of review Although surgical modalities and therapies have been made great progress in recent years, however, there is still an urgent need to alleviate its increased burden. Hence, understanding the precise pathophysiological signaling mechanisms and all other factors of such skin insults will be beneficial for the development of more efficient therapies. Key scientific concepts of review In this review, we explained new understandings about onset and development of skin cancer and described its management via polymeric micro/nano carriers-based therapies, highlighting the current key bottlenecks and future prospective in this field. In therapeutic drug/gene delivery approaches, polymeric carriers-based system is the most promising strategy. This review discusses that how polymers have successfully been exploited for development of micro/nanosized systems for efficient delivery of anticancer genes and drugs overcoming all the barriers and limitations associated with available conventional therapies. In addition to drug/gene delivery, intelligent polymeric nanocarriers platforms have also been established for combination anticancer therapies including photodynamic and photothermal, and for theranostic applications. This portfolio of latest approaches could promote the blooming growth of research and their clinical availability. |
Databáze: | OpenAIRE |
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