Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Autor: Xin-Ying Ji, Muhammad Farhan Khan, Asim Ur Rehman, Mahnoor Baloch, Lei Qian, Dongdong Wu, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Maria Mir
Rok vydání: 2022
Předmět:
0301 basic medicine
Medicine (General)
Skin Neoplasms
Science (General)
Polymers
Mn
Manganese
MSC
Melanoma skin cancer
PLA-HPG
Poly (d-l-lactic acid)-hyperbranched polyglycerol
Pharmaceutical Science
PATCH1
Patch
SCC
Squamous cell Carcinoma
PCL
Poly (ε-caprolactone)
Disease
5-ALA
5-aminolevulinic acid
PLL
Poly (L-lysine)
Polyethylene Glycols
Q1-390
Drug Delivery Systems
hTERT
Human telomerase reverse transcriptase
0302 clinical medicine
Polymeric nanocarriers
Squamous cell carcinoma
UV
Ultra Violet
Gene delivery
PDT
Photodynamic therapy
PLGA
Poly (lactide-co-glycolide) copolymers
media_common
Multidisciplinary
Melanoma
GNR-PEG-MN
PEGylated gold nanorod microneedle
CREB
response element-binding protein
SC
Skin cancer
PEG
Polyethylene glycol
IPM
Isopropyl myristate
030220 oncology & carcinogenesis
HPMC
Hydroxypropyl methylcellulose
Drug delivery
NMSC
Non melanoma skin cancer
BCC
Basal cell carcinoma
MNPs
Magnetic nanoparticle
dPG
Dendritic polyglycerol
cAMP
Cyclic adenosine monophosphate
Microneedles
Drug
medicine.medical_specialty
BCCs
Basal cell carcinomas
SPIO
Superparamagnetic iron oxide
media_common.quotation_subject
NPs
Nano Particles
MRI
Magnetic Resonance Imaging
DDS
Drug delivery system
MNs
Microneedles
03 medical and health sciences
R5-920
medicine
Humans
SMO
Smoothen
Intensive care medicine
Biology
AIDS
Acquired immune deficiency syndrome
ComputingMethodologies_COMPUTERGRAPHICS
PLA
Poly lactic acid
PAMAM
Poly-amidoamines
Cancer
HH
Hedgehog
DIM-D
Di indolyl methane derivative
medicine.disease
Nanostructures
Gd
Gadolinium
030104 developmental biology
MCIR
Melanocortin-1 receptor
Basal cell carcinoma
PAN
Polyacrylonitrile
5-FU
5-fluorouracil
Skin cancer
OTR
Organ transplant recipients
QDs
Quantum dots
Zdroj: Journal of Advanced Research, Vol 36, Iss, Pp 223-247 (2022)
Journal of Advanced Research
ISSN: 2090-1232
Popis: Graphical abstract
Highlights • Skin cancer is a fatal public health concern rising continuously all over the world. • Several environmental and genetic risk factors are associated with cutaneous carcinogenesis. • Use of nanocarriers for targeted delivery of anticancer agents is the most advanced approach. • Polymeric structures are suitable for tumor selective delivery of drugs, genes and imaging agents. • Polymeric micro/nanostructures have successfully used for combination anticancer therapies.
Background Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers, and lack of efficient drug delivery systems, it is essential to surge the possible ways to prevent or cure the disease. Aim of review Although surgical modalities and therapies have been made great progress in recent years, however, there is still an urgent need to alleviate its increased burden. Hence, understanding the precise pathophysiological signaling mechanisms and all other factors of such skin insults will be beneficial for the development of more efficient therapies. Key scientific concepts of review In this review, we explained new understandings about onset and development of skin cancer and described its management via polymeric micro/nano carriers-based therapies, highlighting the current key bottlenecks and future prospective in this field. In therapeutic drug/gene delivery approaches, polymeric carriers-based system is the most promising strategy. This review discusses that how polymers have successfully been exploited for development of micro/nanosized systems for efficient delivery of anticancer genes and drugs overcoming all the barriers and limitations associated with available conventional therapies. In addition to drug/gene delivery, intelligent polymeric nanocarriers platforms have also been established for combination anticancer therapies including photodynamic and photothermal, and for theranostic applications. This portfolio of latest approaches could promote the blooming growth of research and their clinical availability.
Databáze: OpenAIRE
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