Repeated transcranial direct current stimulation reduces food craving in Wistar rats
| Autor: | Vanessa Leal Scarabelot, Éllen Almeida Nunes, Isabel Cristina de Macedo, Andrieli Daiane Zdanski de Souza, Wolnei Caumo, Iraci Lucena da Silva Torres, C. I. de Oliveira, Gabriela Laste, Felipe Fregni, Liciane Fernandes Medeiros, Jonnsin Kuo, Rafael Vercelino |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Brain activity and meditation medicine.medical_treatment Hypothalamus Physiology Prefrontal Cortex Stimulation Craving Anxiety Transcranial Direct Current Stimulation 03 medical and health sciences Random Allocation 0302 clinical medicine Weight Loss medicine Animals Rats Wistar Prefrontal cortex General Psychology Neurons Nutrition and Dietetics Transcranial direct-current stimulation Behavior Animal Appetite Regulation Brain-Derived Neurotrophic Factor digestive oral and skin physiology Feeding Behavior Overweight Dorsolateral prefrontal cortex 030104 developmental biology medicine.anatomical_structure Food craving Brain stimulation Exploratory Behavior medicine.symptom Psychology Energy Intake Neuroscience 030217 neurology & neurosurgery Biomarkers Locomotion |
| Zdroj: | Appetite. 103 |
| ISSN: | 1095-8304 |
| Popis: | It has been suggested that food craving-an intense desire to consume a specific food (particularly foods high in sugar and fat)-can lead to obesity. This behavior has also been associated with abuse of other substances, such as drugs. Both drugs and food cause dependence by acting on brain circuitry involved in reward, motivation, and decision-making processes. The dorsolateral prefrontal cortex (DLPFC) can be activated following evocation and is implicated in alterations in food behavior and craving. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique capable of modulates brain activity significantly, has emerged as a promising treatment to inhibit craving. This technique is considered safe and inexpensive; however, there is scant research using animal models. Such studies could help elucidate the behavioral and molecular mechanisms of eating disorders, including food craving. The aim of our study was to evaluate palatable food consumption in rats receiving tDCS treatment (anode right/cathode left). Eighteen adult male Wistar rats were randomized by weight and divided into three groups (n = 6/group): control, with no stimulation; sham, receiving daily 30 s tDCS (500 μA) sessions for 8 consecutive days; and tDCS, receiving daily 20 min tDCS (500 μA) sessions for 8 consecutive days. All rats were evaluated for locomotor activity and anxiety-like behavior. A palatable food consumption test was performed at baseline and on treatment completion (24 h after the last tDCS session) under fasting and feeding conditions and showed that tDCS decreased food craving, thus corroborating human studies. This result confirms the important role of the prefrontal cortex in food behavior, which can be modulated by noninvasive brain stimulation. |
| Databáze: | OpenAIRE |
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