Eight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruses
| Autor: | Francisco del Pozo, Inmaculada Casas, María Luz García-García, Cristina Calvo, Ana Tabares, Cristina A. F. Roman, Rosa Sanchez-Dehesa |
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| Přispěvatelé: | Instituto de Salud Carlos III |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Rhinovirus Adenoviridae Infections Population Parvoviridae Infections lcsh:Medicine Respiratory Syncytial Virus Infections medicine.disease_cause Adenoviridae Orthomyxoviridae Infections Internal medicine Human bocavirus Medicine Humans education lcsh:Science Child Retrospective Studies education.field_of_study Multidisciplinary Picornaviridae Infections biology Respiratory tract infections business.industry lcsh:R virus diseases Infant biology.organism_classification medicine.disease Orthomyxoviridae Virology eye diseases Respiratory Syncytial Viruses Hospitalization Pneumonia Bronchiolitis Child Preschool lcsh:Q Female business Research Article |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid PLoS ONE Repisalud Instituto de Salud Carlos III (ISCIII) PLoS ONE, Vol 10, Iss 7, p e0132162 (2015) |
| Popis: | Human adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections. This study has been supported by FIS (Fondo de Investigaciones Sanitarias – Spanish Health Research Fund) Grants N°: PI06/0532, PS09/0246, and PI12/0129. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Sí |
| Databáze: | OpenAIRE |
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