Fetal Vascular Responses to Maternal Glucose Administration in Streptozocin-Induced Ovine Diabetes Mellitus
| Autor: | Jan E. Dickinson, Bruce A. Meyer, Sue M. Palmer |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Radioactive microsphere technique Cardiovascular System Streptozocin Diabetes Mellitus Experimental Fetus Diabetes mellitus Internal medicine medicine Animals Kidney Sheep business.industry Hemodynamics Obstetrics and Gynecology Blood flow medicine.disease Glucose Endocrinology medicine.anatomical_structure Hyperglycemia Gestation business Perfusion Homeostasis |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 24:325-333 |
| ISSN: | 1447-0756 1341-8076 |
| DOI: | 10.1111/j.1447-0756.1998.tb00104.x |
| Popis: | Objective:To assess the impact of administration of a glucose load to the pregnant diabetic ewe on fetal biochemistry and umbilical-placental perfusion. Methods: Six pregnant ewes were rendered glucose intolerant by the administration of streptozocin at 85–90 days gestation. An intravenous glucose load was administered to the 6 diabetic ewes and 4 control animals at 125—130 days gestation. Assessment of the fetal responses to this glucose load was made by cardiovascular monitoring, biochemical evaluation and measurement of fetal blood flows by the radioactive microsphere technique. Results:In the fetus of the diabetic ewe the arterial pH progressively decreased from 7.36±0.04 to 7.10±0.09 (p |
| Databáze: | OpenAIRE |
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