Pediatric Invasive Fungal Risk Score in Cancer and Hematopoietic Stem Cell Transplantation Patients With Febrile Neutropenia
| Autor: | Lena Elmuti, Mihai Giurcanu, Madan Kumar, Muayad Alali |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents medicine.medical_treatment Hematopoietic stem cell transplantation Neutropenia Logistic regression Risk Factors Neoplasms Internal medicine Humans Medicine Child Febrile Neutropenia Retrospective Studies Framingham Risk Score business.industry Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology Odds ratio medicine.disease Pediatric cancer Oncology Pediatrics Perinatology and Child Health business Febrile neutropenia |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 44:e334-e342 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0000000000002242 |
| Popis: | BACKGROUND Invasive fungal diseases (IFDs) are opportunistic infections that result in significant morbidity and mortality in pediatric oncology patients. Predictive risk tools for IFD in pediatric cancer are not available. METHODS We conducted a 7-year retrospective study of pediatric oncology patients with a diagnosis of febrile neutropenia at UCM Comer Children's Hospitals. Fourteen clinical, laboratory, and treatment-related risk factors for IFD were analyzed. Stepwise variable selection for multiple logistic regression was used to develop a risk prediction model for IFD. Two comparative analyses have been conducted: (i) all suspected IFD cases and (ii) all proven and probable IFD cases. RESULTS A total of 667 febrile neutropenia episodes were identified in 265 patients. IFD was diagnosed in 62 episodes: 13 proven, 27 probable, and 22 possible. In the final multiple logistic regression models, 5 variables were independently significant for both analyses: fever days, neutropenia days, hypotension, and absolute lymphocyte count |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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