Expanding the clinical use of standard OGTT: the percentage increment of 2 h with respect to fasting glucose as an index of β-cell dysfunction
| Autor: | Roberto Mella, Gian Paolo Fra, Marcello Bigliocca, Ettore Bartoli, E. Scaglia, E. Colli, G.P. Carnevale Schianca |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Endocrinology Diabetes and Metabolism Cell Fasting glucose Endocrinology Insulin resistance Internal medicine Diabetes mellitus Insulin-Secreting Cells Insulin Secretion Internal Medicine medicine Glucose homeostasis Humans Insulin Oral glucose tolerance business.industry Insulin sensitivity Type 2 Diabetes Mellitus Fasting Glucose Tolerance Test medicine.disease medicine.anatomical_structure Diabetes Mellitus Type 2 Insulin Resistance business |
| Zdroj: | Diabetes/metabolism research and reviews. 27(3) |
| ISSN: | 1520-7560 |
| Popis: | Aims Since glucose levels during oral glucose tolerance test (OGTT) are determined both by insulin sensitivity and insulin secretion, we investigated whether the percentage increment (PG%) of 2-h plasma glucose (2hPG) over fasting plasma glucose (FPG) is related to validated indexes of insulin sensitivity and insulin secretion. Methods Using Stumvoll's formulas we calculated estimated insulin sensitivity index and first-phase insulin secretion in 1281 subjects who underwent a standard OGTT. The ratio first-phase insulin secretion/(1/estimated insulin sensitivity index) was considered a surrogate index of β-cell function. For each subject we calculated PG% using the formula: [(2hPG − FPG)/FPG] × 100. For each glucose tolerance group we formed tertiles based on PG% values. Results In each glucose tolerance group, β-cell function was better preserved in lower PG% tertiles, demonstrating a correlation between PG% and insulin resistance. Conclusions By a simple calculation, our study allows, expansion of the clinical use of OGTT to recognize subjects liable to further worsening of glucose homeostasis, independent from glucose tolerance groupings. Copyright © 2011 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text