The early diagnostic value of C-reactive protein for anastomotic leakage post radical gastrectomy for esophagogastric junction carcinoma: A retrospective study of 97 patients
| Autor: | Tie Wang, Lining Tian, Litong Ji, Meizhuo Gao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Anastomotic Leak 030230 surgery Sensitivity and Specificity Gastroenterology 03 medical and health sciences 0302 clinical medicine Gastrectomy Stomach Neoplasms Internal medicine Carcinoma Humans Medicine Radical surgery Esophagogastric junction Aged Retrospective Studies Radical gastrectomy biology business.industry C-reactive protein Retrospective cohort study General Medicine Middle Aged medicine.disease Surgery C-Reactive Protein Early Diagnosis Anastomotic leakage 030220 oncology & carcinogenesis biology.protein Female Esophagogastric Junction business |
| Zdroj: | International Journal of Surgery. 27:182-186 |
| ISSN: | 1743-9191 |
| DOI: | 10.1016/j.ijsu.2016.02.021 |
| Popis: | Background/Aims The incidence of esophagogastric junction (EGJ) carcinoma has increased worldwide. The only curable strategy for EGJ carcinoma is surgery, whereas anastomotic leakage is the major complication after operations. We aimed to test whether the serum levels of C-reactive protein have the diagnostic value for anastomotic leakage after surgery for EGJ carcinoma. Methods In this study, we analyzed the values of CRP before and 5 continuous days after surgery in 97 EGJ carcinoma patients who received surgery as the initial treatment. The levels of CRP in the groups of EGJ patients with or without anastomotic leakage were compared. Results The CRP levels of patients with anastomotic leakage elevated faster and remained higher compared patients without anastomotic leakage. The CRP value at Day 2 after radical surgery for EGJ carcinoma patients has the early diagnostic value for anastomotic leakage. The cut-off value of CRP for anastomotic leakage at Day 2 is 177 mg/l with the sensitivity of 0.9 and specificity of 0.95 (P Conclusion Surgical EGJ carcinoma patients with elevated CRP at Day 2 after surgery should be excluded the possibility of anastomotic leakage. |
| Databáze: | OpenAIRE |
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