Hypermethylation of repetitive DNA elements in livers of mice fed an atherogenic diet
| Autor: | Suna Kim, Taekyung Yoo, Jae Hoon Chung, Soo Hee Ryu, Young Soo Yoon, Cheol O. Joe, Ji Yun Ahn, Tae Youl Ha |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Endocrinology Diabetes and Metabolism Mice Obese Biology Epigenesis Genetic chemistry.chemical_compound Mice Internal medicine medicine Animals Epigenetics Obesity Repeated sequence Obese Mice Repetitive Sequences Nucleic Acid Atherogenic diet Nutrition and Dietetics Genome Methylation DNA DNA Methylation Atherosclerosis Mice Inbred C57BL Endocrinology Biochemistry chemistry Liver DNA methylation Diet Atherogenic |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 28(2) |
| ISSN: | 1873-1244 |
| Popis: | Objective DNA methylation status was examined in C57BL/6J obese mice fed an atherogenic diet (AD) to establish the correlation between epigenetic alterations and obesity-related abnormalities. Methods Six-week-old male C57BL/6J mice were fed a normal diet (ND) or AD for 8 wk. Methylation levels of global DNA and repetitive DNA elements in livers of ND-fed mice and AD-fed mice were examined. Results The total amounts of 5-MeC genomic contents in livers of AD-fed mice were increased as compared with those of ND-fed mice. Hypermethylation of repetitive DNA elements was observed in livers of AD-fed mice. Conclusion Hypermethylation of repetitive DNA elements in livers of AD-fed mice proposes epigenetic changes by nutritional intervention. |
| Databáze: | OpenAIRE |
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