COVID-19 severity in asthma patients: A multi-center matched cohort study

Autor: Liqin Wang, Zachary S. Wallace, Kimberly G. Blumenthal, Aidan A. Long, Yuqing Zhang, Xiaoqing Fu, Lacey B. Robinson, Carlos A. Camargo
Rok vydání: 2020
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
Allergy
2019-20 coronavirus outbreak
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
medicine.medical_treatment
Review
medicine.disease_cause
Lower risk
Cystic fibrosis
03 medical and health sciences
0302 clinical medicine
Sex Factors
Matched cohort
immune system diseases
Internal medicine
medicine
Immunology and Allergy
Humans
030212 general & internal medicine
Coronavirus
Aged
Proportional Hazards Models
Asthma
Aged
80 and over
Mechanical ventilation
SARS-CoV-2
business.industry
Hazard ratio
Age Factors
Patient Acuity
Interstitial lung disease
COVID-19
Middle Aged
asthma
allergy
medicine.disease
Respiration
Artificial
respiratory tract diseases
Hospitalization
030228 respiratory system
Pediatrics
Perinatology and Child Health
Female
business
Boston
Zdroj: The Journal of Asthma
article-version (VoR) Version of Record
DOI: 10.1101/2020.10.02.20205724
Popis: ObjectiveThe evidence pertaining to the effects of asthma on Coronavirus disease 2019 outcomes has been unclear. To improve our understanding of the clinically important association of asthma and Coronavirus disease 2019.MethodsA matched cohort study was performed using data from the Mass General Brigham Health Care System (Boston, MA). Adult (age ≥ 18 years) patients with confirmed Coronavirus disease 2019 and without chronic obstructive pulmonary disease, cystic fibrosis, or interstitial lung disease between March 4, 2020 and July 2, 2020 were analyzed. Up to 5 non-asthma comparators were matched to each asthma patient based on age (within 5 years), sex, and date of positive test (within 7 days). The primary outcomes were hospitalization, mechanical ventilation, and death, using multivariable Cox-proportional hazards models accounting for competing risk of death, when appropriate. Patients were followed for these outcomes from diagnosis of Coronavirus disease 2019 until July 2, 2020.ResultsAmong 562 asthma patients, 199 (21%) were hospitalized, 15 (3%) received mechanical ventilation, and 7 (1%) died. Among the 2686 matched comparators, 487 (18%) were hospitalized, 107 (4%) received mechanical ventilation, and 69 (3%) died. The adjusted Hazard Ratios among asthma patients were 0.99 (95% Confidence Internal 0.80, 1.22) for hospitalization, 0.69 (95% Confidence Internal 0.36, 1.29) for mechanical ventilation, and 0.30 (95% Confidence Internal 0.11, 0.80) for death.ConclusionsIn this matched cohort study from a large Boston-based healthcare system, asthma was associated with comparable risk of hospitalization and mechanical ventilation but a lower risk of mortality.
Databáze: OpenAIRE
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