Functional development in clinical high risk youth: Prediction of schizophrenia versus other psychotic disorders

Autor: Scott W. Woods, Ming T. Tsuang, Sarah I. Tarbox, Jean Addington, Diana O. Perkins, Elaine F. Walker, Larry J. Seidman, Robert K. Heinssen, Thomas H. McGlashan, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt
Rok vydání: 2014
Předmět:
Male
Longitudinal study
Medical and Health Sciences
Risk Factors
Diagnosis
Adaptation
Psychological
Longitudinal Studies
Aetiology
Young adult
Pediatric
Psychiatry
Prodrome
Serious Mental Illness
Adolescence
Social adjustment
Prospective
Psychiatry and Mental health
Mental Health
Schizophrenia
Female
Schizophrenic Psychology
social and economic factors
Psychology
Social Adjustment
Developmental psychopathology
Clinical psychology
Psychosis
medicine.medical_specialty
Adolescent
Premorbid
behavioral disciplines and activities
Article
Young Adult
Clinical Research
2.3 Psychological
mental disorders
medicine
Humans
Adaptation
Schizophreniform disorder
Biological Psychiatry
Prevention
Psychology and Cognitive Sciences
medicine.disease
Brain Disorders
Psychotic Disorders
Psychological
Follow-Up Studies
Zdroj: Psychiatry research, vol 215, iss 1
ISSN: 0165-1781
DOI: 10.1016/j.psychres.2013.10.006
Popis: This study evaluates premorbid social and academic functioning in clinical high-risk individuals as predictors of transition to schizophrenia versus another psychotic disorder. Participants were 54 individuals enrolled in phase one of the North American Prodrome Longitudinal Study who over two and a half years of follow-up met criteria for schizophrenia/schizophreniform disorder (n = 28) or another psychotic disorder (n = 26). Social and academic functioning in childhood, early adolescence, and late adolescence was assessed at baseline using the Cannon-Spoor Premorbid Adjustment Scale. Social maladjustment in late adolescence predicted significantly higher odds of transition to schizophrenia versus another psychotic disorder independent of childhood and early adolescent adjustment (OR = 4.02) and conveyed unique risk over academic maladjustment (OR = 5.64). Premorbid academic maladjustment was not associated with psychotic disorder diagnosis. Results support diagnostic specificity of premorbid social dysfunction to schizophrenia in clinical high-risk youth and underscore an important role for social maladjustment in the developmental pathology of schizophrenia and its prediction.
Databáze: OpenAIRE
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