Disrupted metabolic and functional connectivity patterns of the posterior cingulate cortex in cirrhotic patients: a study combining magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging
| Autor: | Mengjie Lu, Zhiqiang Zhang, Ling Ni, Muhammad Umair Sami, Kai Xu, Li Lu, Jun-Peng Wang, Longjiang Zhang, Guang Ming Lu, Rongfeng Qi, Xiang Kong |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Magnetic Resonance Spectroscopy Metabolite Rest Creatine Gyrus Cinguli 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Prospective Studies Hepatic encephalopathy General Neuroscience Nuclear magnetic resonance spectroscopy Middle Aged medicine.disease Magnetic Resonance Imaging Cortex (botany) Glutamine Endocrinology chemistry Posterior cingulate Female Analysis of variance Nerve Net 030217 neurology & neurosurgery |
| Zdroj: | Neuroreport. 29(12) |
| ISSN: | 1473-558X |
| Popis: | The association between metabolic activity and functional coupling of the posterior cingulate cortex (PCC) in cirrhotic patients remains undefined. Therefore, this study aimed to assess the association of functional coupling with metabolic patterns of PCC in resting cirrhotic patients. Twenty-six cirrhotic patients, including 10 with hepatic encephalopathy (HE) and 16 without HE, were assessed, alongside 21 control participants. Single-voxel proton magnetic resonance spectroscopy (MRS) of the PCC and resting-state functional MRI (rs-fMRI) were performed on a 3.0-T MR scanner. The ratios of all metabolites to creatine (Cr) and rs-fMRI parameters [including amplitude of low-frequency fluctuation (ALFF), node degree (Ki), and betweenness centrality (Bi)] were evaluated by analysis of variance. Associations of metabolite ratios with rs-fMRI parameters and venous ammonia were determined by Pearson's correlation analysis. Lower chlorine (Cho)/Cr (0.6±0.2 vs. 0.9±0.1, P |
| Databáze: | OpenAIRE |
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