The evolution of the axonal transport toolkit
| Autor: | Oscar M. Lazo, Andrew P. Tosolini, Elena R. Rhymes, James N. Sleigh, Giampietro Schiavo, Sandy Richter, Edoardo Moretto, Sunaina Surana, David Villarroel-Campos |
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| Rok vydání: | 2019 |
| Předmět: |
Kinesins
Biology Axonal Transport Models Biological Biochemistry 03 medical and health sciences 0302 clinical medicine Structural Biology Genetics medicine Animals Humans Neuronal degeneration Axon Molecular Biology Scientific disciplines 030304 developmental biology Neurons 0303 health sciences Bidirectional transport Cell Biology Axons Biological materials Cell biology medicine.anatomical_structure nervous system Axoplasmic transport Kinesin Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Traffic. 21:13-33 |
| ISSN: | 1600-0854 1398-9219 |
| DOI: | 10.1111/tra.12710 |
| Popis: | Neurons are highly polarized cells that critically depend on long-range, bidirectional transport between the cell body and synapse for their function. This continual and highly coordinated trafficking process, which takes place via the axon, has fascinated researchers since the early 20th century. Ramon y Cajal first proposed the existence of axonal trafficking of biological material after observing that dissociation of the axon from the cell body led to neuronal degeneration. Since these first indirect observations, the field has come a long way in its understanding of this fundamental process. However, these advances in our knowledge have been aided by breakthroughs in other scientific disciplines, as well as the parallel development of novel tools, techniques and model systems. In this review, we summarize the evolution of tools used to study axonal transport and discuss how their deployment has refined our understanding of this process. We also highlight innovative tools currently being developed and how their addition to the available axonal transport toolkit might help to address key outstanding questions. |
| Databáze: | OpenAIRE |
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