Host and Viral Factors Affecting the Decreased Immunogenicity of Sabin Type 3 Vaccine after Administration of Trivalent Oral Polio Vaccine to Rural Mayan Children
| Autor: | Linda Logan, F Millan-Velasco, S M Matsui, José Luis Valdespino, Yvonne Maldonado, Jaime Sepúlveda, M de la Luz Sanchez, Michael F Cantwell, S Blandón, V Peña-Cruz |
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| Rok vydání: | 1997 |
| Předmět: |
Rural Population
viruses Dose-Response Relationship Immunologic Antibodies Viral medicine.disease_cause complex mixtures Major Articles Astrovirus Feces Rotavirus parasitic diseases medicine Humans Immunology and Allergy Child Developing Countries Mexico biology Polyvalent Vaccine business.industry Poliovirus Immunogenicity virus diseases biology.organism_classification Virology Enteritis Vaccination Poliovirus Vaccine Inactivated Infectious Diseases Poliovirus Vaccine Oral Immunology Indians North American Regression Analysis Enterovirus Public Health Viral disease business Immunity Maternally-Acquired |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/175.3.545 |
| Popis: | Factors affecting immunogenicity of the first 2 doses of oral poliovirus vaccine (OPV) among unimmunized Mayan infants were prospectively evaluated. The relative impact of multiple variables, including mass or routine vaccination, concurrent enteric bacterial (salmonella, shigella, and campylobacter) and viral (adenovirus 40/41, astrovirus, nonpolio enteroviruses, and rotavirus) infections, interference among Sabin vaccine viruses, and preexisting poliovirus antibodies were studied. Sera were available from 181 infants after 2 OPV doses. Seroresponses were 86% to Sabin type 1, 97% to Sabin type 2, and 61% to Sabin type 3 vaccines. Mass versus routine vaccination and preexisting poliovirus antibodies did not affect immunogenicity. By multiple logistic regression analysis, fecal shedding of homologous Sabin strains was associated with increased seroresponses to all Sabin types, especially to Sabin type 3. Decreased OPV immunogenicity was primarily attributable to interference of Sabin type 3 by Sabin type 2. OPV formulations with higher doses of Sabin type 3 could improve immunogenicity among infants in developing countries. |
| Databáze: | OpenAIRE |
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