Systolic pressure predicts plasma vasopressin responses to hemorrhage and vena caval constriction in dogs
| Autor: | Terry N. Thrasher, Lanny C. Keil |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Vasopressin Baroreceptor Vasopressins Physiology Ganglionic Blockers Hypovolemia Hemodynamics Aorta Thoracic Blood Pressure Hemorrhage Vena Cava Inferior Constriction Dogs Predictive Value of Tests Physiology (medical) medicine Animals Ventricular Function Heart Atria Anesthetics Local Ligation Blood Volume business.industry Baroreflex Atrial Function Arginine Vasopressin Disease Models Animal Blood pressure Anesthesia Circulatory system Reflex Regression Analysis Female medicine.symptom business Procaine |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 279:R1035-R1042 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | We have proposed that the reflex increase in arginine vasopressin (AVP) secretion in response to hypovolemia is due to arterial baroreceptor unloading. If arterial pressure is the key to the mechanism, the slope relating plasma AVP to arterial pressure should be the same in response to hemorrhage, a model of true hypovolemia, and in response to thoracic inferior vena caval constriction (IVCC), a model of central hypovolemia. We tested this hypothesis in conscious, chronically instrumented dogs ( n = 8). The mean coefficient of determination ( r 2) values obtained from the individual regressions of log AVP onto systolic pressure (SP) and mean arterial pressure (MAP) in response to hemorrhage were 0.953 ± 0.009 and 0.845 ± 0.047, respectively. Paired comparisons indicated a significant difference between the means ( P < 0.05), hence, SP was used in subsequent analyses. The mean slopes relating the log of plasma AVP to SP in response to hemorrhage and IVCC were −0.034 ± 0.003 and −0.032 ± 0.002, respectively, and the means were not significantly different ( P = 0.7). The slopes were not altered when the experiments were repeated during acute blockade of cardiac receptors by intrapericardial procaine. Finally, sinoaortic denervation ( n = 4) markedly reduced the slope in both the hemorrhage and IVCC treatments. We conclude that baroreceptors monitoring arterial pressure provide the principal reflex control of AVP secretion in response to hypovolemia. |
| Databáze: | OpenAIRE |
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