Effects of Cancer, Chemotherapy, and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer
Autor: | Vincent Chin-Hung Chen, Robert Stewart, Han-Pin Hsiao, Yen-Hsuan Hsu, Bor-Show Tzang, Chin-Kuo Lin, Shu-I Wu |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment chemotherapy Article 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Verbal fluency test cancer Cognitive skill RC254-282 Chemotherapy business.industry Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cognition medicine.disease neuropsychological testing cytokines Cytokine inflammation 030220 oncology & carcinogenesis subjective and objective cognitive functioning Anxiety medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Cancers Volume 13 Issue 11 Cancers, Vol 13, Iss 2576, p 2576 (2021) |
ISSN: | 2072-6694 |
DOI: | 10.3390/cancers13112576 |
Popis: | Background: We aimed to investigate the associations of breast cancer (BC) and cancer-related chemotherapies with cytokine levels, and cognitive function. Methods: We evaluated subjective and objective cognitive function in BC patients before chemotherapy and 3~9 months after the completion of chemotherapy. Healthy volunteers without cancer were also compared as control group. Interleukins (IL) 2, 4, 5, 6, 10, 12p70, 13, 17A, 1β, IFNγ, and TNFα were measured. Associations of cancer status, chemotherapy and cytokine levels with subjective and objective cognitive impairments were analyzed using a regression model, adjusting for covariates, including IQ and psychological distress. Results: After adjustment, poorer performance in semantic verbal fluency was found in the post-chemotherapy subgroup compared to controls (p = 0.011, η2 = 0.070) whereas pre-chemotherapy patients scored higher in subjective cognitive perception. Higher IL-13 was associated with lower semantic verbal fluency in the post-chemotherapy subgroup. Higher IL-10 was associated with better perceived cognitive abilities in the pre-chemotherapy and control groups while IL-5 and IL-13 were associated with lower perceived cognitive abilities in pre-chemotherapy and control groups. Our findings from mediation analysis further suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Conclusions: Our findings suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Different cytokines and their interactions may have different roles of neuroinflammation or neuroprotection that need further research. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |