Sustained Low Efficiency Dialysis in the Continuous Mode (C-SLED)
| Autor: | Abdulla K. Salahudeen, Joshua Samuels, Kristen Price, Lianchun Xiao, Niti Madan, Joseph L. Nates, Amit Lahoti, Vikas Kumar |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Epidemiology Critical Illness Multiple Organ Failure medicine.medical_treatment Blood Pressure Kaplan-Meier Estimate Critical Care and Intensive Care Medicine Risk Assessment Blood Urea Nitrogen Renal Dialysis Risk Factors Neoplasms Internal medicine medicine Humans Blood urea nitrogen Serum Albumin Dialysis Aged Proportional Hazards Models Retrospective Studies Transplantation Proportional hazards model business.industry Mortality rate Acute kidney injury Original Articles Acute Kidney Injury Hydrogen-Ion Concentration Middle Aged Creatine medicine.disease Surgery Treatment Outcome Parenteral nutrition Blood pressure Nephrology Female Parenteral Nutrition Total SOFA score business Biomarkers |
| Zdroj: | Clinical Journal of the American Society of Nephrology. 4:1338-1346 |
| ISSN: | 1555-9041 |
| Popis: | Background and objectives: Oliguric, hypotensive patients who require large amounts of fluids may benefit from sustained low-efficiency dialysis performed continuously (C-SLED). C-SLED through higher clearance may improve survival, or through greater nutritional loss may worsen survival. No studies have assessed survival on C-SLED. The objective was to examine patient outcomes and survival predictors on C-SLED. Design, setting, participants, & measurements: The data of 199 consecutive cancer patients treated with C-SLED were analyzed. The median duration of C-SLED was 50 h. With 48 h of C-SLED, the blood urea nitrogen (BUN) and serum creatinine levels had decreased by 80% and 73%, respectively. The mean arterial pressure (MAP) was maintained despite higher ultrafiltration and reduced vasopressor use. The 30-d mortality rate was 65%. Despite excellent dialysis, the sequential organ failure assessment (SOFA) score remained predictive of mortality. In the univariate model, higher SOFA scores and lower values for MAP, blood pH, and serum albumin and creatinine levels were associated with higher mortality. Administration of total parenteral nutrition (TPN) was, however, associated with lower mortality. Results: In the multivariate model, the higher SOFA score and lower blood pH, MAP and C-SLED duration were associated with higher mortality. In a subset analysis of 129 patients who received C-SLED for at least 48 h, those with higher BUN levels, which were associated with higher TPN infusion, had a lower mortality risk. Conclusion: This first detailed report on C-SLED indicates that C-SLED can be effective and suggests a link between nutrition and survival. |
| Databáze: | OpenAIRE |
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