Analysis of crotonaldehyde puff-by-puff release in mainstream cigarette smoke under various smoking regimens by high-performance liquid chromatography with the modified QuEChERS method
| Autor: | Li Chao, Ying Tao, Chengming Zhang, Xiaofeng Shen, Li Exian, Ya Liu, Jian Zhang, Yunhua Qin |
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| Rok vydání: | 2018 |
| Předmět: |
QuEChERS
010501 environmental sciences Quechers 01 natural sciences High-performance liquid chromatography chemistry.chemical_compound stomatognathic system crotonaldehyde intensive smoking regimens Cigarette smoke Crotonaldehyde lcsh:Science 0105 earth and related environmental sciences puff-by-puff release Multidisciplinary Chromatography 010401 analytical chemistry respiratory tract diseases 0104 chemical sciences body regions Chemistry chemistry lcsh:Q RM20H smoking machine sense organs Research Article |
| Zdroj: | Royal Society Open Science Royal Society Open Science, Vol 5, Iss 6 (2018) |
| ISSN: | 2054-5703 |
| Popis: | To study puff-by-puff release characteristics of crotonaldehyde in mainstream cigarette smoke under diverse intensive smoking regimens, we designed an RM20H smoking machine with a puff-by-puff smoke collection unit to automatically trap crotonaldehyde in the mainstream cigarette smoke. Using this process, we trapped, puff-by-puff, crotonaldehyde in mainstream smoke generated by different smoking regimens and quantitatively analysed the levels of crotonaldehyde using high-performance liquid chromatography with a modified QuEChERS sample pretreatment method. On the basis of the crotonaldehyde in each puff, we determined crotonaldehyde's puff-by-puff release characteristics. The results showed that crotonaldehyde's puff-by-puff release remained nearly constant for the International Organization for Standardization mode while increased polynomial trend was seen ( n ≥ 6) under the Massachusetts and Health Canada smoking regimens. The equation fit for various regimens was good ( R 2 > 0.9192). Release characteristics by puff were classified into four categories: (1) first, second and third puffs; (2) fourth and fifth puffs; (3) sixth puff; and (4) seventh and eighth puffs. |
| Databáze: | OpenAIRE |
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