HDAC-selective Inhibitor Cay10603 Has Single Anti-tumour Effect in Burkitt’s Lymphoma Cells by Impeding the Cell Cycle
| Autor: | Yang Fan, Fang Chen, Jianing Miao, Zhijie Li, Di Wu, Gang Xu, Xiu-Juan Ma, Yue Zhan |
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| Rok vydání: | 2019 |
| Předmět: |
Antineoplastic Agents
Apoptosis Biochemistry Histone Deacetylases immune system diseases Cyclin-dependent kinase Cell Line Tumor hemic and lymphatic diseases Genetics medicine Humans Cell Proliferation Cyclin biology Chemistry Cell Cycle Cell cycle HDAC6 medicine.disease Burkitt Lymphoma Lymphoma Histone Deacetylase Inhibitors Cell culture Cancer research biology.protein Burkitt's lymphoma |
| Zdroj: | Current Medical Science. 39:228-236 |
| ISSN: | 2523-899X 2096-5230 |
| DOI: | 10.1007/s11596-019-2024-4 |
| Popis: | Histone deacetylases (HDACs) inhibitors are novel in cancer therapy nowadays. HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity. We explored the anti-tumor effect and the molecular mechanism of cay10603, a potent HDAC6 inhibitor in Burkitt's lymphoma cells. Our study revealed cay10603 inhibited the proliferation of Burkitt's lymphoma cell lines, and induced caspase-dependent apoptosis. Cay10603 inhibited the expression of CDKs and cyclins to impede cell cycle progression in both Burkitt's lymphoma cell lines. Cay10603 also showed the additive effect with vp16 notably. Our data presented the promising anti-tumor effect of cay10603 in the Burkitt's lymphoma therapy. |
| Databáze: | OpenAIRE |
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