Developmental regulation of expression of schizophrenia susceptibility genes in the primate hippocampal formation
| Autor: | Grégoire Favre, P Banta Lavenex, Pierre Lavenex |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Time Factors hippocampus Hippocampus Epigenetics of schizophrenia autism spectrum disorder Hippocampal formation 03 medical and health sciences Cellular and Molecular Neuroscience Apolipoproteins E 0302 clinical medicine Gene expression medicine Animals CA1 Region Hippocampal Methylenetetrahydrofolate Reductase (NADPH2) Biological Psychiatry 030304 developmental biology Serotonin Plasma Membrane Transport Proteins Brain-derived neurotrophic factor 0303 health sciences Brain-Derived Neurotrophic Factor Gene Expression Profiling Dentate gyrus Gene Expression Regulation Developmental medicine.disease CA3 Region Hippocampal Macaca mulatta Williams schizophrenia Gene expression profiling Psychiatry and Mental health Schizophrenia Dentate Gyrus Alzheimer epilepsy Original Article Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scopus-Elsevier Translational Psychiatry, vol. 2, pp. e173 Translational Psychiatry |
| Popis: | The hippocampal formation is essential for normal memory function and is implicated in many neurodevelopmental, neurodegenerative and neuropsychiatric disorders. In particular, abnormalities in hippocampal structure and function have been identified in schizophrenic subjects. Schizophrenia has a strong polygenic component, but the role of numerous susceptibility genes in normal brain development and function has yet to be investigated. Here we described the expression of schizophrenia susceptibility genes in distinct regions of the monkey hippocampal formation during early postnatal development. We found that, as compared with other genes, schizophrenia susceptibility genes exhibit a differential regulation of expression in the dentate gyrus, CA3 and CA1, over the course of postnatal development. A number of these genes involved in synaptic transmission and dendritic morphology exhibit a developmental decrease of expression in CA3. Abnormal CA3 synaptic organization observed in schizophrenics might be related to some specific symptoms, such as loosening of association. Interestingly, changes in gene expression in CA3 might occur at a time possibly corresponding to the late appearance of the first clinical symptoms. We also found earlier changes in expression of schizophrenia susceptibility genes in CA1, which might be linked to prodromal psychotic symptoms. A number of schizophrenia susceptibility genes including APOE, BDNF, MTHFR and SLC6A4 are involved in other disorders, and thus likely contribute to nonspecific changes in hippocampal structure and function that must be combined with the dysregulation of other genes in order to lead to schizophrenia pathogenesis. |
| Databáze: | OpenAIRE |
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