Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia
| Autor: | Marcelo A. Soares, Frosso Voulgaropoulou, Benjamin R. Tan, Beatrice H. Hahn, Lee Ratner |
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| Předmět: |
T-Lymphocytes
Molecular Sequence Data Immunology HIV Infections Viral quasispecies HIV Envelope Protein gp120 Biology V3 loop Microbiology Virus Cell Line Bone Marrow Virology medicine Humans Amino Acid Sequence Peptide sequence Cellular compartment chemistry.chemical_classification virus diseases Thrombocytopenia Amino acid medicine.anatomical_structure chemistry Cell culture Insect Science HIV-1 Pathogenesis and Immunity Bone marrow Sequence Alignment |
| Zdroj: | Scopus-Elsevier |
| Popis: | We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia. |
| Databáze: | OpenAIRE |
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