Control of infection with multiple antibiotic resistant bacteria in a hospital renal unit: the value of plasmid characterization
| Autor: | T. Cheasty, C. S. Reed, S. P. Barrett, E. J. Threlfall |
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| Rok vydání: | 1995 |
| Předmět: |
Epidemiology
medicine.drug_class Klebsiella pneumoniae R Factors Antibiotics Ceftazidime Aztreonam Biology Enterobacter aerogenes Disease Outbreaks Microbiology chemistry.chemical_compound Antibiotic resistance Gram-Negative Bacteria medicine Humans Citrobacter Cross Infection biology.organism_classification Drug Resistance Multiple United Kingdom Infectious Diseases chemistry Seasons Hospital Units Research Article Piperacillin medicine.drug |
| Zdroj: | Epidemiology and Infection. 115:61-70 |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s095026880005812x |
| Popis: | SummaryAn outbreak of infections due to multiple antibiotic-resistant bacteria took place over a period of approximately 18 months in a renal unit. Strains ofEscherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Citrobacterspp. andPseudomonasspp. were involved, and a variety of antibiotic resistances was encountered. Closely related plasmids encoding resistance to aztreonam, ceftazidime and piperacillin, possibly derived from an archetypal plasmid of 105 kb were found in the majority of isolates examined. After limiting the use of aztreonam the incidence of new patient isolates of multiple-resistant organisms was greatly reduced. This study demonstrated how molecular studies can contribute to the control of an outbreak situation in a hospital unit by providing an impetus to reduce the use of specific antibiotics. |
| Databáze: | OpenAIRE |
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