Relative contribution of cognitive and physical disability components to quality of life in MS

Autor: Krista Cleynhens, Marie-Claire Haelewyck, Mieke D'hooge, Jacques De Keyser, Mélanie De Schepper, Guy Nagels, Jeroen Van Schependom, Marie B. D'hooghe
Přispěvatelé: Internal Medicine Specializations, Neuroprotection & Neuromodulation
Předmět:
Zdroj: Vrije Universiteit Brussel
Popis: Background Information on the relative influence of cognitive and physical impairment on the quality of life in multiple sclerosis is currently limited and no scientific consensus has been reached yet. Objective For this reason, we wanted to examine the relative contribution of cognitive and physical impairment measures comprised in the MSFC test on quality of life in MS. Methods In the National MS Center Melsbroek, patients regularly undergo MSFC and EQ5D measurements. We investigated the correlations between the EQ5D, EQVAS and the MSFC and EDSS scores by the use of ANOVA and multilinear models. Results We found a significant correlation between the EQVAS score and cognition in a univariate model. When including EDSS score and MSFC outcomes into the model, cognition was, however, excluded based on the Akaike Information Criterion. Cognition was, on the other hand, a significant predictor for the “Usual Activities” question of the EQ5D. Conclusions Although cognitive performance as measured on the PASAT-3s does not correlate with a patient's perceived quality of life in a multivariate model, it remains an important predictor for the patient's usual activities.
Databáze: OpenAIRE