Maneuverability of Magnetic Nanomotors Inside Living Cells
| Autor: | Ambarish Ghosh, Ramray Bhat, Anumeha Singh, Sandeep M. Eswarappa, Neha Somalwar, Deepak Kumar Saini, Malay Pal |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
02 engineering and technology 010402 general chemistry Biochemistry 01 natural sciences Cellular viability Magnetics Motion Nanotechnology General Materials Science Molecular Reproduction Development & Genetics Physics Mechanical Engineering Biophysical Phenomena 021001 nanoscience & nanotechnology 0104 chemical sciences Electrical Communication Engineering Magnetic Fields Mechanics of Materials Active manipulation Others Centre for Nano Science and Engineering Biophysics Anisotropy 0210 nano-technology Intracellular |
| Zdroj: | Advanced Materials. 30:1800429 |
| ISSN: | 0935-9648 |
| DOI: | 10.1002/adma.201800429 |
| Popis: | Spatiotemporally controlled active manipulation of external micro-/nanoprobes inside living cells can lead to development of innovative biomedical technologies and inspire fundamental studies of various biophysical phenomena. Examples include gene silencing applications, real-time mechanical mapping of the intracellular environment, studying cellular response to local stress, and many more. Here, for the first time, cellular internalization and subsequent intracellular manipulation of a system of helical nanomotors driven by small rotating magnetic fields with no adverse effect on the cellular viability are demonstrated. This remote method of fuelling and guidance limits the effect of mechanical transduction to cells containing external probes, in contrast to ultrasonically or chemically powered techniques that perturb the entire experimental volume. The investigation comprises three cell types, containing both cancerous and noncancerous types, and is aimed toward analyzing and engineering the motion of helical propellers through the crowded intracellular space. The studies provide evidence for the strong anisotropy, heterogeneity, and spatiotemporal variability of the cellular interior, and confirm the suitability of helical magnetic nanoprobes as a promising tool for future cellular investigations and applications. |
| Databáze: | OpenAIRE |
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