Epidermal growth factor attenuates lingual papillae lesions in a rat model of sialoadenectomy
| Autor: | Asmaa A. A. Kattaia, Samia A. Abd El-Baset, Assmaa O. Selim, Sally A. Selim |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Saliva Taste Esophageal Mucosa Rat model Biology Salivary Glands 03 medical and health sciences 0302 clinical medicine stomatognathic system Tongue Epidermal growth factor Internal medicine medicine Animals Humans Lingual papilla Epidermal Growth Factor Mouth Mucosa Cell Biology General Medicine Taste Buds Rats 030104 developmental biology medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis hormones hormone substitutes and hormone antagonists Developmental Biology |
| Zdroj: | Tissuecell. 63 |
| ISSN: | 1532-3072 |
| Popis: | Salivary epidermal growth factor (EGF) plays an important role in the maintenance of the oral and gastro-esophageal mucosa. Sialoadenectomy delays healing of oral wounds and affects lingual papillae. In this work, we aimed to determine the effect of EGF deficiency induced by sialoadenectomy and evaluate the effect of exogenous EGF administration on the lingual papillae and taste buds in rats. Thirty male adult Wistar albino rats were equally divided into 3 groups; sham-operated control group, sialoadenectomy group and group of sialoadenectomy + EGF. EGF was given 8 weeks after sialoadenectomy in a dose of 1 μg /ml/day in drinking water for 2 weeks. The anterior two-thirds of the tongue was dissected and cut longitudinally into two halves; one half for light microscope and the other for electron microscope examinations. Saliva and blood were collected to determine salivary and plasma EGF. Our results revealed that sialoadenectomy significantly reduced plasma and saliva levels of EGF which resulted in severe disruption of the architecture of lingual papillae. These changes were effectively improved by the exogenous EGF administration. In conclusion, EGF supplementation reversed the effects of sialoadenectomy and restored almost normal architecture of lingual papillae and taste buds. |
| Databáze: | OpenAIRE |
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