The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China
| Autor: | Peng Li, Yi Hong Ling, Mu Yan Cai, Xin Ke Zhang, Yuan Fang Li, Rong Zhen Luo, Chong Mei Zhu, Hao Qiang He, Wan Ming Hu, Dan Xie, Jing Ping Yun |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male Oncology China medicine.medical_specialty Cancer Research Lymphovascular invasion medicine.medical_treatment Young Adult Stomach Neoplasms Surgical oncology Internal medicine medicine Genetics Humans Stage (cooking) Lymph node Survival analysis Aged Retrospective Studies Aged 80 and over business.industry Cancer Middle Aged Prognosis medicine.disease Survival Analysis medicine.anatomical_structure Lymphatic Metastasis Female Lymphadenectomy Gastrectomy Neoplasm Recurrence Local Gastric cancer business Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-015-1370-2 |
| Popis: | Background The focus of this study was to assess the impact of lymphovascular invasion (LVI) on both the recurrence of cancer and the long-term survival of Chinese patients with resectable gastric cancer (GC). Methods A retrospective analysis of the clinicopathological data for 1148 GC patients who had undergone gastrectomy with regional lymphadenectomy was performed. The primary objective was to assess the correlation between LVI and post-surgery outcomes for each patient. This was done by routine H & E staining for LVI on patients’ disease-free survival (DFS) and disease-specific survival (DSS). Results LVI was detected in 404 (35.2%) of the 1148 GC patients. The presence of LVI was significantly correlated with the level of CA19-9, the tumor size, the Lauren classification, tumor differentiation, gastric wall invasive depth, lymph node involvement, distant metastasis and an advanced TNM stage. There was a lower DFS and DSS in the patients with LVI as compared to the patients without LVI. A multivariate analysis also identified LVI as an independent prognostic factor of both DSS and DFS. Conclusions The presence of LVI is a risk factor for the recurrence of cancer and an independent indicator of a poor outcome in GC patients following surgery. The LVI status should be taken into consideration when determining the best approach for the treatment of the individual. |
| Databáze: | OpenAIRE |
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