Sézary syndrome with a 14:14 (q12:q31) translocation
| Autor: | Ila Shah-Reddy, Kazutoshi Mayeda, Fred Koppitch, Ila Mirchandani |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Cytoplasm
Cancer Research Pathology medicine.medical_specialty Hepatosplenomegaly Lymph node biopsy Erythroderma Chromosomal translocation Translocation Genetic Ataxia Telangiectasia Leukocyte Count Bone Marrow White blood cell medicine Humans Sezary Syndrome Lymphocytes Aged Cell Nucleus medicine.diagnostic_test business.industry Cell Membrane medicine.disease medicine.anatomical_structure Oncology Skin biopsy Female Bone marrow medicine.symptom business Chromosomes Human 13-15 Generalized lymphadenopathy |
| Zdroj: | Cancer. 49:75-79 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19820101)49:1<75::aid-cncr2820490116>3.0.co;2-4 |
| Popis: | The Sézary syndrome was diagnosed in a 71-year-old black woman with erythroderma, generalized lymphadenopathy and hepatosplenomegaly. The laboratory data revealed a white blood cell count of 65,000 mm3 with 81% lymphocytes, the majority having an indented or a cerebriform nucleus. The skin biopsy, the lymph node biopsy and immunologic surface marker studies confirmed the diagnosis of Sézary syndrome. The cytogenetic studies of the bone marrow and the peripheral blood revealed a (14:14) (q12:q31) translocation present, consistently in majority of the lymphocytes. This translocation is considered characteristic of ataxia-telangiectasia and, to our knowledge, has not been previously described in Sézary syndrome. |
| Databáze: | OpenAIRE |
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