Nitroglycerin, or Not, When Treating Impending Filler Necrosis
| Autor: | Joel L. Cohen, Sama K Carley, Christina N. Kraus |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Filler (packaging) Necrosis Administration Topical Vasodilator Agents Dermatology Cosmetic Techniques 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Nitroglycerin Young Adult 0302 clinical medicine Hyaluronidase Injection Hyaluronidase Dermal Fillers Hyaluronic acid Medicine Humans Hyaluronic Acid Skin business.industry Soft tissue General Medicine Middle Aged Surgery chemistry 030220 oncology & carcinogenesis Tissue necrosis medicine.symptom business medicine.drug |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 46(1) |
| ISSN: | 1524-4725 |
| Popis: | Background Dermal necrosis is a rare yet serious risk associated with cosmetic filler injections, and although current consensus recommends the use of hyaluronidase injections in cases of hyaluronic acid filler, the efficacy of topical nitroglycerin as a treatment has not yet been fully investigated. Objective To review the literature on tissue necrosis resulting from soft tissue augmentation and to highlight the use of topical nitroglycerin as a first-line treatment. Methods A review of the literature was performed with no time limitations resulting in 35 articles and 66 patients who experienced tissue necrosis secondary to injectable fillers. Articles were reviewed for pertinent information and presented. Results Only 7 of the 66 reported cases (10%) used topical nitroglycerin as a treatment. Six of 7 (85%) were successful in halting the impending necrosis. Fifty-nine patients received alternative treatments, with hyaluronidase injection being the most common. Few reports of novel treatments for necrosis included the use of topical growth factors and injection of adipose-derived stem cells. Conclusion Topical nitroglycerin is a potentially effective and underused treatment for tissue necrosis from soft tissue augmentation, but because data are very limited, topical nitroglycerin should be used in conjunction with hyaluronidase injections in cases of hyaluronic acid filler dermal necrosis. |
| Databáze: | OpenAIRE |
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