Chemotherapeutic Potential of Carthamus Oxycantha Root Extract as Antidiarrheal and In Vitro Antibacterial Activities
| Autor: | Adedayo Olukanni, Gaber El-Saber Batiha, Nasir A. Siddiqui, Muhammad Kifayatullah, Muhammad Ikram, Muhammad Zahoor, Masood Shah, Ahmed Shaban Abdelaziz, Muhammad Amin, Amany Magdy Beshbishy, Muhammad Naeem, Riaz Ullah, Ramzi A. Mothana |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) methanolic extract Salmonella typhi medicine.disease_cause Biochemistry Microbiology 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine antibacterial activity antidiarrheal medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics MIC (minimum inhibitory concentration) Antibacterial agent Traditional medicine biology Chemistry lcsh:RM1-950 Carthamus Antimicrobial biology.organism_classification lcsh:Therapeutics. Pharmacology 030104 developmental biology Infectious Diseases Staphylococcus aureus 030220 oncology & carcinogenesis Castor oil Carthamus oxycantha Antibacterial activity medicine.drug |
| Zdroj: | Antibiotics Volume 9 Issue 5 Antibiotics, Vol 9, Iss 226, p 226 (2020) |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics9050226 |
| Popis: | Our research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400&thinsp mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p < 0.001) decreased the frequency of defecation, and wet stools in a dose depended on the manner of after receiving magnesium sulfate (2 g/kg (b.w)) and castor oil (1.0 mL/mice). Furthermore, the extract of C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5&ndash 15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action. |
| Databáze: | OpenAIRE |
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