Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort

Autor: Maurice P. Zeegers, Sylvia H J Jochems, Patrick Rump, Marij Gielen, Gerard Hornstra
Přispěvatelé: Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Linoleic acid
Clinical Biochemistry
Blood lipids
Blood Pressure
BLOOD-PRESSURE
Biology
Body Mass Index
FISH-OIL SUPPLEMENTATION
Cohort Studies
chemistry.chemical_compound
Insulin resistance
Fetal origins
Essential fatty acid
Metabolic Diseases
Risk Factors
DUTCH FAMINE
Internal medicine
medicine
Humans
Child
Maternal-Fetal Exchange
PRENATAL EXPOSURE
chemistry.chemical_classification
Pregnancy
INSULIN-RESISTANCE
HEART-RATE-VARIABILITY
Fatty Acids
Essential
Infant
Newborn
Fatty acid
Cell Biology
LINOLEIC-ACID
medicine.disease
Eicosapentaenoic acid
Endocrinology
Glucose
PLASMA PHOSPHOLIPIDS
ADIPOSE-TISSUE
PREGNANCY
chemistry
Cardiovascular Diseases
Fatty Acids
Unsaturated
Female
Polyunsaturated fatty acids
Prenatal programming
Cardiometabolic disease risk
Polyunsaturated fatty acid
Zdroj: Prostaglandins Leukotrienes and Essential Fatty Acids, 100, 21-27. ELSEVIER SCI LTD
ISSN: 0952-3278
DOI: 10.1016/j.plefa.2015.06.001
Popis: Background: Increasing evidence suggests that long-chain polyunsaturated fatty acid (LCPUFA) availability in utero could program later health.Objective: The objective of the study was to explore whether prenatal LCPUFA availability could be involved in programming cardiometabolic disease risk at childhood. Methods: Data of 242 mother child pairs from the Maastricht Essential Fatty Acid Birth (MEFAB) cohort were used. Multi-variable linear regression analysis was applied to identify associations between maternal LCPUFA concentrations around weeks 11, 22 and 32 of pregnancy and at time of delivery and cardiometabolic risk factors of their children (glucose metabolism, blood lipids, and blood pressure) at age 7.Results: Maternal eicosapentaenoic acid (20:5n-3) at week 11 of pregnancy was negatively associated with children's glucose (B=-0.34 mmol/L; 95% CI: -0.56, -0.12). Positive associations were found between maternal linoleic acid (18:2n-6) at time of delivery and children's proinsulin (B=0.25 pmol/L; 95% Cl: 0.08, 0.41); maternal 3-docosapentaenoic acid (22:5n-3) at week 11 and children's total cholesterol (B=1.23 mmol/L; 95% Cl: 0.45, 2.01) and low-density-lipoprotein cholesterol (B=1.12 mmol/L; 95% CI: 0.42, 1.82); and maternal osbond acid (22:5n-6) at week 22 and tetracosadienoic acid (24:2n-6) at week 32 and children's diastolic blood pressure (B=16.86 mmHg; 95% Cl: 7.63, 26.08 and B=17.75 mmHg; 95% Cl: 6.37, 29.94, respectively).Conclusion: Our findings suggest that maternal omega-6 (n-6) fatty acids may be of particular importance in relation to children's glucose metabolism and blood pressure, whereas omega-3 (n-3) fatty acids seem particularly related to blood lipids at childhood. In general, the strength of the associations appeared stronger with fatty acid concentrations in early pregnancy compared to late pregnancy. (C) 2015 Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: