Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

Autor: Mandy Sanders, Hilde E. Smith, Nicholas J. Croucher, James A. Leigh, Inna Cherevach, Sarah Sharp, Michael A. Kehoe, Matthew T. G. Holden, To Song Diep, Jianguo Xu, Duncan J. Maskell, Thi Hoa Ngo, Philip N. Ward, Tran Thi Bich Chieu, Karen Mungall, Michael A. Quail, Christopher G. Dowson, Pernille Iversen, Brian G. Spratt, Adrian M. Whatmore, Constance Schultsz, Ian Goodhead, Marcelo Gottschalk, Julian Parkhill, Nguyen Thi Hoang Mai, Ester Rabbinowitsch, N. Chanter, Josh Slater, Heidi Hauser, Claire Price, Ann Cronin, Nguyen Tran Chinh, Stephen J. Bentley, Barclay G. Barrell, Changyun Ye
Přispěvatelé: University of St Andrews. School of Medicine, University of St Andrews. Infection Group, University of St Andrews. Biomedical Sciences Research Complex, AII - Amsterdam institute for Infection and Immunity, Infectious diseases
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Streptococcus suis
lcsh:Medicine
Genome
Disease Outbreaks
Zoonoses
lcsh:Science
Phylogeny
Genetics
0303 health sciences
Microbiology/Microbial Evolution and Genomics
Multidisciplinary
Virulence
Bacteriologie
Drug Resistance
Microbial
Bacteriology
Host Pathogen Interaction & Diagnostics
3. Good health
RB Pathology
Horizontal gene transfer
Science & Technology - Other Topics
Research Article
DNA
Bacterial
General Science & Technology
Pseudogene
Genomics
Biology
Microbiology
03 medical and health sciences
SDG 3 - Good Health and Well-being
Streptococcal Infections
MD Multidisciplinary
Life Science
Animals
Humans
030304 developmental biology
Host Pathogen Interaction & Diagnostics
Comparative genomics
Science & Technology
Infectious Diseases/Antimicrobials and Drug Resistance
030306 microbiology
MULTIDISCIPLINARY SCIENCES
lcsh:R
Microbiology/Medical Microbiology
Bacteriology
biology.organism_classification
Host Pathogen Interactie & Diagnostiek
QR
Bacteriologie
Host Pathogen Interactie & Diagnostiek
Microbial genetics
lcsh:Q
RB
Genome
Bacterial
Zdroj: PLoS ONE
PLoS ONE (2009)
PLoS ONE, Vol 4, Iss 7, p e6072 (2009)
PLoS ONE, 4(7). Public Library of Science
ISSN: 1932-6203
Popis: This work was supported by the Wellcome Trust. Background: Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly understood. Methodology/Principal Findings: The sequencing of whole genomes of S. suis isolates provides opportunities to investigate the genetic basis of infection. Here we describe whole genome sequences of three S. suis strains from the same lineage: one from European pigs, and two from human cases from China and Vietnam. Comparative genomic analysis was used to investigate the variability of these strains. S. suis is phylogenetically distinct from other Streptococcus species for which genome sequences are currently available. Accordingly, similar to 40% of the similar to 2 Mb genome is unique in comparison to other Streptococcus species. Finer genomic comparisons within the species showed a high level of sequence conservation; virtually all of the genome is common to the S. suis strains. The only exceptions are three similar to 90 kb regions, present in the two isolates from humans, composed of integrative conjugative elements and transposons. Carried in these regions are coding sequences associated with drug resistance. In addition, small-scale sequence variation has generated pseudogenes in putative virulence and colonization factors. Conclusions/Significance: The genomic inventories of genetically related S. suis strains, isolated from distinct hosts and diseases, exhibit high levels of conservation. However, the genomes provide evidence that horizontal gene transfer has contributed to the evolution of drug resistance. Publisher PDF
Databáze: OpenAIRE
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