Role of Leukocytes and Endothelial Cells in the Development of Angiogenesis in Inflammation and Wound Healing

Autor:	M W, Lingen
Rok vydání:	2001
Předmět:	Inflammation Wound Healing Medical Laboratory Technology Neovascularization Pathologic Macrophages Leukocytes Animals Humans Neovascularization Physiologic Endothelium Vascular General Medicine History 20th Century Pathology and Forensic Medicine
Zdroj:	Archives of Pathology & Laboratory Medicine. 125:67-71
ISSN:	1543-2165 0003-9985
Popis:	The basic signs and symptoms of inflammation and wound healing have been appreciated for thousands of years. However, the specific cells involved and their roles in this complex environment are still being elucidated today. In 1926, the origin of the phagocytic mononuclear ameboid wandering cell (macrophage) had not been determined. One popular theory was that the cells were differentiated from the endothelial cells of the nearby blood vessels, whereas others believed that the cells came from the peripheral blood or resting wandering cells. The purpose of this article is to review the seminal article published by Lang regarding this topic nearly 75 years ago. In addition, this article will review what is now known with regard to the role of the macrophage and endothelial cells in the development of angiogenesis, which is arguably the most critical component of successful inflammatory process or wound healing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44dd671c04bc35b9670e286619b3be42 https://doi.org/10.5858/2001-125-0067-rolaec Zobrazit plný text záznamu