The Antiarrhythmic Effects of Sophora Flavescens Ait. in Rats and Mice
| Autor: | Soter Dai, Mo-Yin Chan, Shiuh-Sheng Lee, Clive W. Ogle |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Aconitine Pharmacology Ventricular tachycardia Mice chemistry.chemical_compound Left coronary artery medicine.artery medicine Animals cardiovascular diseases Medicine Chinese Traditional Ligation Medicine East Asian Traditional Mice Inbred ICR Plants Medicinal Sophora flavescens biology Plant Extracts business.industry Arrhythmias Cardiac Rats Inbred Strains General Medicine biology.organism_classification medicine.disease Coronary Vessels Rats Artery ligation Complementary and alternative medicine chemistry cardiovascular system business Anti-Arrhythmia Agents |
| Zdroj: | The American Journal of Chinese Medicine. 14:119-123 |
| ISSN: | 1793-6853 0192-415X |
| DOI: | 10.1142/s0192415x86000193 |
| Popis: | The effects of an ethanol extract of the plant Sophora flavescens Ait. on cardiac arrhythmias induced by coronary artery ligation in rats, and by aconitine infusion in mice, were studied. Pretreatment with intravenous injection of the extract, 120 mg/kg, significantly reduced the incidence and delayed the onset of ventricular tachycardia in rats subjected to ligation of the left coronary artery. The time of onset of both initial cardiac arrhythmias and prersistent ventricular tachycardia induced by aconitine infusion in mice was also significantly prolonged. These preliminary findings suggest that the ethanol extract of Sophara flavescens Ait. possesses antiarrhythmic activity. |
| Databáze: | OpenAIRE |
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