Selections From Current Literature: Screening For Colorectal Cancer
| Autor: | Mirza I Rahman, Marius E Chagoury |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Oncology medicine.medical_specialty Colorectal cancer Population Colonoscopy law.invention Randomized controlled trial law Internal medicine medicine Humans Mass Screening education Intensive care medicine Sigmoidoscopy Aged Randomized Controlled Trials as Topic Genetic testing Aged 80 and over education.field_of_study Modalities medicine.diagnostic_test business.industry Middle Aged medicine.disease United States Occult Blood Female False positive rate Colorectal Neoplasms Family Practice business |
| Zdroj: | Family Practice. 11:333-339 |
| ISSN: | 1460-2229 0263-2136 |
| DOI: | 10.1093/fampra/11.3.333 |
| Popis: | Of the five modalities currently used to screen for colorectal cancer, the DRE is the least useful as a solitary screening tool. Also, while FOBT is widely used, its high false positive rate and uncertain cost benefit ratio make it less than ideal as a screening tool. Flexible sigmoidoscopy in a well defined regimen, has been shown to result in a decrease in CRC mortality. Paramedical personnel with a moderate amount of training have been shown to be able to safely and efficiently perform screening sigmoidoscopy. This has the potential to make it widely available at an affordable cost to the general population; however, its limitations, namely its ability to detect only lesions found in the distal colon, need to be kept in mind. With all limitations in the above mentioned screening modalities, colonoscopy may be the best tool to detect colorectal cancers. It has a significant advantage over DCBE of being both a diagnostic and therapeutic tool; however, it is imperative that a randomized controlled trial be performed to fully document its potential efficacy, advantages and disadvantages. Finally while genetic testing looms on the horizon as a promising new tool for CRC screening, at this time there are still too many unanswered questions and dilemmas, ethical as well as others, to warrant its use in the general clinical setting. However, maybe in the future, CRC screening will involve a simple blood test performed at birth, or perhaps even prenatally. |
| Databáze: | OpenAIRE |
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